The 301st was one of four African-American fighter squadrons to enter combat during World War II.
One of the famous all-black squadrons of the 332d Fighter Group, it was activated on 19 February 1942 at Tuskegee Army Air Field, Alabama, but remained largely unmanned until it arrived at Selfridge Field, Michigan late in March 1943. There it received a full complement of personnel and the squadron began operational training with Bell P-39 Airacobra and Curtiss P-40 Warhawk aircraft. The unit completed training in December 1943 and prepared to move overseas.